Ophthalmoscopic examination of the left eye revealed numerous yellowish-white plaques involving the major branches of the central retinal artery in a 55-year-old man. Significant laboratory examinations demonstrated hyperlipidemia with hypercholesterolemia. A diagnosis of occlusive vascular disease of the left retina caused by atherosclerotic plaques was made. The patient was treated with heparin and clofibrate, with no significant change in ophthalmoscopic appearance of the plaques or in the lipid values in his blood. After sudden death 15 months later, both eyes were obtained. Gross examination of the left eye disclosed numerous yellowishwhite plaques in retinal arteries, corresponding exactly to those previously observed ophthalmoscopically. Two plaques demonstrated that they represented multiple atheromas of retinal vessels.
Brownstein S, Font RL, Alper MG. Atheromatous Plaques of the Retinal Blood VesselsHistologic Confirmation of Ophthalmoscopically Visible Lesions. Arch Ophthalmol. 1973;90(1):49-52. doi:10.1001/archopht.1973.01000050051010