Findings are reported for a 47-year-old man with Werner syndrome. He is prematurely old, has diabetes mellitus of adult onset, skin atrophy, poliosis, and characteristic posterior subcapsular cataracts. Additional ocular features compatible with premature aging in this man include diminished tear flow, arcus senilis, and reduced accommodation. Slight venous tortuosity, and mild leakage of fluorescein in the macular area of each eye were the only minimal findings suggestive of diabetic retinopathy. Cataract surgery in these patients may be hazardous.
Bullock JD, Howard RO. Werner Syndrome. Arch Ophthalmol. 1973;90(1):53-56. doi:10.1001/archopht.1973.01000050055011