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October 1973

Ocular Findings in a Kindred With Kyrle DiseaseHyperkeratosis Follicularis et Parafollicularis in Cutem Penetrans

Author Affiliations

From the departments of ophthalmology and pathology, University of Illinois Eye and Ear Infirmary, Chicago.

Arch Ophthalmol. 1973;90(4):278-280. doi:10.1001/archopht.1973.01000050280005

Kyrie disease, a follicular keratosis which may develop at any age in either sex and occur anywhere on the body except the palms, soles, and mucous membranes, is characterized by the penetration of a keratotic plug into the dermis, initiating an inflammatory reaction.

Members of a family with Kyrie disease, were examined. The skin disease in this family was relatively benign. However, posterior subcapsular cataracts were present in three young adult members. Two of these patients had multiple tiny yellow-brown anterior stromal corneal opacities.

Analysis of more cases of Kyrie disease is required in order to determine whether or not the ocular findings in this family are coincidental or may indeed be part of the spectrum of Kyrie disease.