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October 1973

Electroretinogram Changes in Acute Quinine Poisoning

Author Affiliations

Iowa City
From the Department of Ophthalmology and the Neurosensory Center, College of Medicine, University of Iowa, Iowa City. Dr. Burian is presently at 1303 Wildwood Dr, Chapel Hill, NC 27514.

Arch Ophthalmol. 1973;90(4):307-309. doi:10.1001/archopht.1973.01000050309014

An experimental model, using rabbits, for acute quinine toxicity is presented. Electroretinogram changes are shown to occur within minutes of the ingestion of 0.5 gm/kg. They consist of increase in a-wave negativity and b-wave depression, which return to normal within 24 hours. These changes should not be due to any action on the ganglion cell and call for a revision of current thinking on quinine toxicity.