A case of fungal ulcer of the cornea resolved after a variety of therapeutic measures, which included amphotericin B and nystatin, were used. Amphotericin B was administered by subconjunctival injections in a total dose of 7.5 mg, which resulted in a severe conjunctival reaction. A unique complication following this therapy was the development of subconjunctival nodules. These were removed and found to contain fibrosing histiocytic areas with intracellular deposits of rod-like PAS-positive material, possibly amphotericin B or a breakdown product of it. Although the conjunctival lesions resolved uneventfully, clinicians should be aware that subconjunctival injection of amphotericin B may result in permanent yellowing of the conjunctiva and that when dosage exceeds 5 mg and the drug is injected subconjunctivally, the development of salmon-colored, raised nodules may be anticipated.
Bell RW, Ritchey JP. Subconjunctival Nodules After Amphotericin B InjectionMedical Therapy for Aspergillus Corneal Ulcer. Arch Ophthalmol. 1973;90(5):402-404. doi:10.1001/archopht.1973.01000050404016