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December 1973

Comparison of Types 1 and 2 Herpesvirus hominis Infection of Rabbit EyesII. Histopathologic and Virologic Studies

Author Affiliations

San Francisco
From Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco. Dr. Stevens is now with Southwestern Medical School, University of Texas, Dallas.

Arch Ophthalmol. 1973;90(6):477-480. doi:10.1001/archopht.1973.01000050477016

In type 2 HVH infections, there was persistent epithelial loss and marked epithelial hyperplasia of the cornea; in type 1 infections, there was rapid recovery from the epithelial loss and by lack of epithelial hyperplasia. The stromal infiltration of inflammatory cells in type 2 infected eyes were deeper and more severe than in the type 1 infection. Infiltration of the endothelium, iris, and choroid by inflammatory cells was more frequently found in type 2 infected eyes than in type 1 infected eyes.

Virus was recovered in high titers in type 1 infections, but ocular inflammation did not persist beyond the 15th to 16th day after inoculation. In contrast, in the type 2 infections, the virus was recovered in much lower titers while the inflammation was severe and persistent through day 31.