The effect of low doses of epinephrine hydrochloride on intraocular pressure was evaluated. Concentrations of ⅛%, ¼%, ½% and 1% epinephrine were administered to one eye of a patient over a four-week period. An interval of four weeks was allowed before the successive higher concentration was applied. The fellow eye was left untreated and served as a control. The results indicate that epinephrine lowers intraocular pressure at the concentrations tested with significantly greater effectiveness at the higher dose levels.
Obstbaum SA, Kolker AE, Phelps CD. Low-Dose EpinephrineEffect on Intraocular Pressure. Arch Ophthalmol. 1974;92(2):118-120. doi:10.1001/archopht.1974.01010010124008