The toxicity and duration of octafluorocyclobutane (C4F8) injected into the anterior chambers of rabbits were compared to those of the same volume of air or sulfur hexafluoride (SF ). A volume of 0.15 ml of C4F8 or SF6 caused increased intraocular pressure, leading to buphthalmos and transitory corneal opacification. Smaller volumes of these gases or 40% mixtures of these gases with air caused minimal toxicity to the anterior chamber structure. The C4F8 consistently lasted longer than SF6 or air.
Brubaker S, Peyman GA, Vygantas C. Toxicity of Octafluorocyclobutane After Intracameral Injection. Arch Ophthalmol. 1974;92(4):324-328. doi:10.1001/archopht.1974.01010010334015