A 17-year-old white male subject with phlyctenular keratitis, superficial candidiasis, and hypoparathyroidism was found to be anergic in delayed hypersensitivity. Reconstitution of the cell-mediated immune response to Candida albicans by means of allogeneic lymphocyte transfusion and by means of transfer factor, and amphotericin B promptly resulted in the clinical remission of the phlyctenulosis and chronic candidiasis.
Wong VG, Kirkpatrick CH. Immune Reconstitution in Keratoconjunctivitis and Superficial CandidiasisThe Role of Immunocompetent Lymphocyte Transfusion and Transfer Factor. Arch Ophthalmol. 1974;92(4):335-339. doi:10.1001/archopht.1974.01010010345018