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October 1974

Immune Reconstitution in Keratoconjunctivitis and Superficial CandidiasisThe Role of Immunocompetent Lymphocyte Transfusion and Transfer Factor

Author Affiliations

From the Georgetown University Medical Center, Washington (Dr. Wong), and the Clinical Allergy and Hypersensitivity Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Md (Dr. Kirkpatrick).

Arch Ophthalmol. 1974;92(4):335-339. doi:10.1001/archopht.1974.01010010345018

A 17-year-old white male subject with phlyctenular keratitis, superficial candidiasis, and hypoparathyroidism was found to be anergic in delayed hypersensitivity. Reconstitution of the cell-mediated immune response to Candida albicans by means of allogeneic lymphocyte transfusion and by means of transfer factor, and amphotericin B promptly resulted in the clinical remission of the phlyctenulosis and chronic candidiasis.