Retinal angiomatosis was found in a 14-year-old male patient during the course of a family survey. The lesion was treated with three sessions of cryotherapy by a multiple freeze-thaw technique to −70 C. As a result of his death from complications of syringobulbia, the eye was able to be obtained for histologic study eight months after therapy. Examination demonstrated complete replacement of the angioma with fibrotic scar and proliferated pigment epithelium except for feeder vessels that were still patent.
Watzke RC. Cryotherapy for Retinal AngiomatosisA Clinicopathologic Report. Arch Ophthalmol. 1974;92(5):399-401. doi:10.1001/archopht.1974.01010010411007