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To the Editor.
—There is some pertinent information regarding the study by Tara et al on "Photodynamic Inactivation of Herpes Simplex Keratitis," which may not have been published when the paper was submitted but which should be available to the readers. In April 1973, in the journal Infection and Immunity (pp 518-519) Varnell and Kaufman published a study comparing photodynamic inactivation with proflavine and treatment with idoxuridine ointment. In this study the proflavine was found to have some effect, but it was trivial compared with the idoxuridine effect. Subsequent to that, Thomas et al (British Journal of Ophthalmology 57:336-338, 1973) published a study very similar to that of Stanley's on photodynamic inactivation of herpes keratitis with neutral red and found that the neutral red treatment did not change the course from the natural course of virus disease. A presentation at the Association for Research in Vision and Ophthalmology, by O'Day
Kaufman HE. Phytodynamic Inactivation of Herpes Simplex Keratitis. Arch Ophthalmol. 1974;92(6):536. doi:10.1001/archopht.1974.01010010550021