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To the Editor.
—Questions have been raised both as to the effectiveness and the safety of photodynamic inactivation of superficial viral infections, in particular herpes simplex keratitis. The very controversy over the effectiveness of this intriguing and unique approach to the treatment of surface infections demands further investigative attention.Our studies have convinced us that photodynamic inactivation does have a favorable effect on the course of herpes simplex keratitis in the rabbit. The response of an established herpes keratitis to photoinactivation, while not dramatic, is at least of the order of that seen to idoxuridine. In addition, we have tested photodynamic inactivation against an idoxuridine-resistant herpes virus, and in this case, the dye-light treatment was far superior to idoxuridine. Dr. Kaufman's point is well taken that idoxuridine, when used intensively, can result in prolonged punctate staining of the cornea. Such staining probably does not represent viral infection but does point
Stanley JA. Phytodynamic Inactivation of Herpes Simplex Keratitis-Reply. Arch Ophthalmol. 1974;92(6):536–537. doi:10.1001/archopht.1974.01010010550022