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February 1975

Corneal Contact Times of Ophthalmic VehiclesEvaluation by Microscintigraphy

Author Affiliations

From the Medical Physics Section of the Department of Radiology (Drs. Trueblood and Carlton), and the Department of Ophthalmology (Drs. Rossomondo and Wilson), Medical College of Georgia, Augusta.

Arch Ophthalmol. 1975;93(2):127-130. doi:10.1001/archopht.1975.01010020133008

Lacrimal microscintigraphy, in conjunction with a recently developed computer system, was used to evaluate the corneal contact time of three ophthalmic vehicles in 18 humans. The percentage of a radioactively labeled vehicle remaining over the cornea after 90 seconds was 2.9% ± 2.2% for saline, 4.3% ± 2.4% for polyvinyl alcohol, and 8.8% ±4.1% for hydroxypropyl methylcellulose.