The effects of vitreous substitution with air, a sulfur hexafluoride-air mixture, an octafluorocyclobutane-air mixture, and physiological saline were compared in owl monkeys. Each gas caused an increase in ocular vascular permeability greater than that caused by saline, as measured by vitreous inflow of serum protein labeled with iodine I 131 and disc-gel electrophoresis. The duration of increased vascular permeability closely paralleled the time each gas remained in the vitreous cavity.
Constable IJ, Swann DA. Vitreous Substitution With Gases. Arch Ophthalmol. 1975;93(6):416-419. doi:10.1001/archopht.1975.01010020430006