A patient had tolerance, habituation, and addiction to the topical use of a combination of cyclopentolate hydrochloride and tropicamide. He also developed a blotchy, diffuse epithelial keratitis that disappeared when the drugs were discontinued.
Ostler HB. Cycloplegics and MydriaticsTolerance, Habituation, and Addiction to Topical Administration. Arch Ophthalmol. 1975;93(6):432-433. doi:10.1001/archopht.1975.01010020446011