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June 1975

Cycloplegics and MydriaticsTolerance, Habituation, and Addiction to Topical Administration

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco.

Arch Ophthalmol. 1975;93(6):432-433. doi:10.1001/archopht.1975.01010020446011

A patient had tolerance, habituation, and addiction to the topical use of a combination of cyclopentolate hydrochloride and tropicamide. He also developed a blotchy, diffuse epithelial keratitis that disappeared when the drugs were discontinued.