A biomicroscopical study of the vitreous body was performed on 116 eyes of 58 patients with primary retinitis pigmentosa, and six additional eyes were examined histopathologically. A characteristic vitreous degeneration, found in all eyes, was clinically divided into four sequential stages that appear to parallel the magnitude of gross retinal destruction as determined by visual-field measurements. The vitreous breakdown in retinitis pigmentosa may be due to progressive loss of hyaluronic acid from the hyaluronic acidcollagen complex.
Pruett RC. Retinitis PigmentosaA Biomicroscopical Study of Vitreous Abnormalities. Arch Ophthalmol. 1975;93(8):603-608. doi:10.1001/archopht.1975.01010020583005