• Eye evaluations before and after 24 weeks of treatment with either ibuprofen (Motrin) or aspirin did not show eye toxicity with either drug in a double-blind study of 78 patients with osteoarthritis. The possibility of eye complications resulting from ibuprofen therapy suggested in two earlier reports has not been confirmed in clinical usage in other countries or in clinical trials in the United States.
Melluish JW, Brooks CD, Ruoff G, Cross CJ, Sanborn EC. Ibuprofen and Visual FunctionProspective Evaluation. Arch Ophthalmol. 1975;93(9):781-782. doi:10.1001/archopht.1975.01010020675003