Plasma carcinoembryonic antigen (CEA) levels were found to be elevated in a 62-year-old woman who came to us with a diffuse choroidal mass in the left eye. Although a metastatic tumor was suspected clinically, a thorough medical evaluation failed to detect a primary lesion and the eye was enucleated. The histologic diagnosis was metastatic adenocarcinoma. On immunohistologic assay, the choroidal metastases stained positively for CEA. We believe this to be the first CEA-positive intraocular tumor to be reported.
Michelson JB, Felberg NT, Shields JA, Foster L. Carcinoembryonic Antigen-Positive Metastatic Adenocarcinoma of the ChoroidA Case Report. Arch Ophthalmol. 1975;93(9):794-796. doi:10.1001/archopht.1975.01010020688005