• Extensive copper infiltration of Descemet membrane of the central cornea and of the anterior and posterior surfaces of the lens is associated with marked hypercupremia related to an abnormal immunoglobulin. Observation of this spectrum of ophthalmic changes in an apparently well middle-aged woman heralded the diagnosis of a unique variety of multiple myeloma.
Lewis RA, Falls HF, Troyer DO. Ocular Manifestations of Hypercupremia Associated With Multiple Myeloma. Arch Ophthalmol. 1975;93(10):1050-1053. doi:10.1001/archopht.1975.01010020824017