• Twelve patients with diffuse drusen of Bruch membrane had their condition evaluated by electro-oculography (EOG). All had normal EOG light-peak/dark-trough ratios, which suggests that the disease does not involve a diffuse functional abnormality of the retinal pigment epithelium. This finding is in contrast to the abnormal EOG ratios reported in patients with fundus flavimaculatus. Categorizing these two diseases along with fundus albipunctatus as flecked retina syndrome should be continued on the basis of the somewhat similar morphologic appearance of the lesions, rather than because of similar results on functional testing.
Fishman GA, Carrasco C, Fishman M. The Electro-oculogram in Diffuse (Familial) Drusen. Arch Ophthalmol. 1976;94(2):231-233. doi:10.1001/archopht.1976.03910030109006