• Seven cases are reported, believed to be the first in the literature, in which iris nodules are verified in the complete spectrum of essential iris atrophies. This feature appears late in the course of the disease as small yellow nodules that progressively increase in number and gradually become dark brown. The differential diagnosis of multiple iris nodules includes neurofibromatosis, melanomas, inflammatory nodules, and developmental anomalies such as iridocorneal dysgenesis.
Shields MB, Campbell DG, Simmons RJ, Hutchinson BT. Iris Nodules in Essential Iris Atrophy. Arch Ophthalmol. 1976;94(3):406-410. doi:10.1001/archopht.1976.03910030194004