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These papers were presented at a conference held at the University of Indiana in January, 1975. Most of the papers are followed by a free discussion which is most interesting and informative.
The clinical triad of disciform macular degeneration, peripapillary choroidal atrophy, and peripheral atrophic spots has been observed for many years and in many countries. A number of ophthalmologists feel that this has something to do with histoplasmosis, since the majority of these patients have a positive skin test for this fungal infection. However, the facts that even in this country, there are a number of patients who have a negative skin test and that this ophthalmoscopic picture is observed in England, Belgium, and Central Europe, where there is no histoplasmosis at all, cast considerable doubt on the etiologic role of Histoplasma capsulatum. In a classic case, the organism has not unequivocally been found in the eye, and one
Blodi FC. Ocular Histoplasmosis. Arch Ophthalmol. 1976;94(7):1240. doi:10.1001/archopht.1976.03910040144029