• Retinal lesions in 116 patients with tuberous sclerosis included three types: the relatively flat, semitransparent, noncalcified tumors; the more commonly described nodular, calcified tumors; and a third lesion that possessed features of the other two. Other less definite pigmented and plaque-like lesions also were seen. The evolution of a relatively flat, noncalcified lesion into an elevated nodular, apparently calcified lesion during an interval of two decades was photographically recorded.
Nyboer JH, Robertson DM, Gomez MR. Retinal Lesions in Tuberous Sclerosis. Arch Ophthalmol. 1976;94(8):1277-1280. doi:10.1001/archopht.1976.03910040149003