• Results of histopathologic examination of the eyes of 15 consecutive patients with metastatic malignant melanoma arising in the skin demonstrated evidence of intraocular metastasis in five patients. The metastases were microscopic, epithelioid, minimally pigmented, and occurred in both the choroid and the retina. All patients were asymptomatic. Those patients with ocular metastases all had primary malignant neoplasms of the superficial, spreading variety and associated central nervous system metastases.
Fishman ML, Tomaszewski MM, Kuwabara T. Malignant Melanoma of the Skin Metastatic to the EyeFrequency in Autopsy Series. Arch Ophthalmol. 1976;94(8):1309-1311. doi:10.1001/archopht.1976.03910040181010