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Volume 16 of Modern Problems in Ophthalmology contains the First International Symposium on Immunology and Immunopathology of the Eye, held in Strasbourg, France, in May 1974. The meeting covered many subjects, including autoimmune mechanisms in uveitis, various problems of ocular immunopathology, viral and parasitic immunopathology, immunologic tests in uveitis, and immunosuppressive therapy.
The longest and most productive session—on autoimmune mechanisms in uveitis—was presented first. Numerous authors emphasized the important role of rod outer segment and retinal pigment epithelial antigens in the induction of experimental autoimmune retino-uveitis. This represents a notable change in thinking among investigators in this field, for organ specific antigens within the uvea were previously considered the focus of immunologic responsiveness in this experimental model. Furthermore, the mechanism by which this disease is produced was seriously questioned. Experimental autoimmune uveitis was successfully produced in guinea pigs by the passive transfer of concentrated serum from enucleated donors. Previous
Kaplan HJ. Ocular Immune Responses: Proceedings of the First International Symposium on Immunology and Immunopathology of the Eye, Strasbourg, 1974,. Arch Ophthalmol. 1976;94(9):1644. doi:10.1001/archopht.1976.03910040474045