• Eighteen glaucoma patients each received four pilocarpine regimens in random sequence: 1% and 4% eyedrops and 20μg/hr and 40μg/hr ocular therapeutic systems. Unimportant changes in refraction, near vision, and distance vision occurred during the use of either ocular therapeutic system. Miosis with ocular therapeutic systems was almost always less intense and variable than with eyedrops. Refractive changes occurred in 12 patients following 1% pilocarpine and in 16 patients following 4% pilocarpine drops; decreased distance vision occurred in nine patients after 1% drops and in 12 patients after 4% drops. Fewer patients showed decreases in near vision. In all cases, visual effects peaked one half hour after eyedrop instillations and returned gradually toward normal in the next two to three hours. Intraocular pressure levels were within comparable ranges during all four treatments, but the ocular therapeutic systems maintained pressure at a more constant level.
Brown HS, Meltzer G, Merrill RC, Fisher M, Ferré C, Place VA. Visual Effects of Pilocarpine in GlaucomaComparative Study of Administration by Eyedrops or by Ocular Therapeutic Systems. Arch Ophthalmol. 1976;94(10):1716-1719. doi:10.1001/archopht.1976.03910040490004