• Nineteen patients with symmetrical ocular hypertension and symmetrical cupping of the optic nerves were made asymmetric with respect to intraocular pressure for one to five years by unilateral topical treatment with epinephrine hydrochloride. Development of glaucomatous visual field defects was observed in 32% of the untreated eyes and in none of the treated eyes (P <.05). Progressive cupping of the optic nerve was noted in 53% of the untreated eyes and in 11 % of the treated eyes (P <.025). Evidence of glaucomatous damage was observed more frequently in subjects maintained on this regimen for longer periods and in subjects with initial horizontal cup/disc ratios greater than 0.4 (P <.05). None of the eyes, either treated or untreated, with mean intraocular pressures less than 24 mm Hg developed glaucomatous damage during the period of this study.
Shin DH, Kolker AE, Kass MA, Kaback MB, Becker B. Long-Term Epinephrine Therapy of Ocular Hypertension. Arch Ophthalmol. 1976;94(12):2059-2060. doi:10.1001/archopht.1976.03910040719002