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Article
February 1977

The Prevalence of HLA-B12 and HLA-B7 Antigens in Primary Open-Angle Glaucoma

Author Affiliations

From the Glaucoma Center, Department of Ophthalmology, and Department of Pathology, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1977;95(2):224-225. doi:10.1001/archopht.1977.04450020026003
Abstract

• HLA-B12 antigen was found in 50% and HLA-B7 was present in 49% of patients with primary open-angle glaucoma. Either one of the antigens B12 or B7 was noted in 88% of such glaucoma patients. The prevalences of B12, B7, or of either antigen were much greater in patients with primary open-angle glaucoma than in the general population or in patients with normal intraocular pressure. The prevalences in patients with ocular hypertension (IOP > 20 mm Hg) were intermediate between the ocular normotensives and the patients with primary open-angle glaucoma. The close association between HLA-B12 and HLA-B7 and primary open-angle glaucoma suggested immunologic components of the disease and possible convenient genetic markers.

(Arch Ophthalmol 95:224-225, 1977)

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