• This article reports a new concept in the treatment of tear film abnormalities. Solubilization of an artificial tear insert provides a continuous flow of polymer into the tear film in place of intermittent drop therapy. The physiochemical properties of succinylated collagen were studied in vitro and compared favorably with presently available tear substitutes. The use of this polymer as a solid solubilizable insert was evaluated in normal patients. It was found to be comfortable, resulted in no blurring of vision, and prolonged the tear film breakup time.
(Arch Ophthalmol 95:247-250, 1977)
Bloomfield SE, Dunn MW, Miyata T, Stenzel KH, Randle SS, Rubin AL. Soluble Artificial Tear Inserts. Arch Ophthalmol. 1977;95(2):247-250. doi:10.1001/archopht.1977.04450020048009