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February 1977

Periocular Injection of CorticosteroidsAn Experimental Evaluation of Its Role in the Treatment of Corneal Inflammation

Author Affiliations

From the Departments of Ophthalmology (Drs Leibowitz and Kupferman) and Pharmacology (Dr Kupferman), Boston University School of Medicine.

Arch Ophthalmol. 1977;95(2):311-314. doi:10.1001/archopht.1977.04450020112019

• The present experiments demonstrate that subconjunctivally injected corticosteroids are less effective in suppressing corneal inflammation than are topically instilled corticosteroids. Topical administration of 6.5 mg of prednisolone acetate over a 30-hour period reduced corneal inflammatory activity by 52%. Subconjunctival injection of 50 mg of the same steroid, also given over a 30-hour period, yielded a 15% reduction in corneal inflammation. A fourfold increase (200 mg) in the quantity of prednisolone acetate injected subconjunctivally resulted in a nonsignificant (P <.05) increment (24%) in anti-inflammatory effect. Dexamethasone sodium phosphate achieved a 30% reduction in corneal inflammation, the maximum effect observed after subconjunctival administration.

The data suggest that different modes of corneal penetration are involved after drug delivery via the two routes. Concurrent administration of corticosteroids by the topical and subconjunctival routes seemingly produced an additive anti-inflammatory effect.

(Arch Ophthalmol 95:311-314, 1977)