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April 1977

Penetrating Keratoplasty in Herpes Simplex KeratitisRecurrence in Grafts

Author Affiliations

From the Department of Ophthalmology (Dr Fine), and the Francis I. Proctor Foundation for Research in Ophthalmology (Dr Cignetti) University of California, San Francisco.

Arch Ophthalmol. 1977;95(4):613-616. doi:10.1001/archopht.1977.04450040079011

• A review of 231 penetrating keratoplasties performed for corneal disease due to herpes simplex keratitis shows that clear grafts may be obtained in 75% and satisfactory visual results in about 70% during a long-term follow-up. Over a three-year follow-up period, recurrence of the herpetic disease in the graft was observed in 12%. Over a longer period of follow-up, up to 15 years, the rate of recurrence increased to 47%. About half of the corneas with recurrence achieved clear grafts with treatment. Recurrence did not appear to be less frequent in those cases which circumscribed scars as compared with those in which there was diffuse scarring. The state of activity of the disease preoperatively could not be demonstrated to influence greatly the results of the keratoplasty.

(Arch Ophthalmol 95:613-616, 1977)