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May 1977

Increased Cellular Responsiveness to Epinephrine in Primary Open-Angle Glaucoma

Author Affiliations

From the Department of Ophthalmology, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1977;95(5):855-856. doi:10.1001/archopht.1977.04450050133016

• The concentration of I-epinephrine hydrochloride necessary to Inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P <.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

(Arch Ophthalmol 95:855-856, 1977)