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Article
May 1977

Ocular Penetration of ChloramphenicolEffects of Route of Administration

Author Affiliations

From the Department of Ophthalmology and Pharmacology, University of Arkansas for Medical Sciences, Little Rock, Ark.

Arch Ophthalmol. 1977;95(5):879-882. doi:10.1001/archopht.1977.04450050157020
Abstract

• Chloramphenicol was applied topically to the eye in ointment, as a powder, or injected subconjunctivally and intravenously in rabbits. Aqueous humor samples were taken at varying time intervals up to six hours and analyzed for chloramphenicol using gas-liquid chromatography. The topical route using ointment and the subconjunctival injection route produced bacteriostatic concentrations of chloramphenicol in the aqueous humor lasting for several hours, while the topical Powder and intravenous routes yielded relatively low concentrations. As compared with the other means of drug delivery, ointment was the most efficient in that it provided the highest aqueous concentration per total amount of drug administered.

(Arch Ophthalmol 95:879-882, 1977)

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