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Epinephrine hydrochloride—Adrin, Glaucon, Adrenaline chloride, Epifrin, Mistura E.
In Reply.—Drance and Anderson raise important questions about the details of our epinephrine hydrochloride studies. They note that the 1966 series excluded patients with a family history of glaucoma and did not require high corticosteroid responsiveness. They failed to note, however, that the 1966 series did not require ocular hypertension but only borderline intraocular pressure (more than one third of the patients included were normotensive throughout the study). It must also be pointed out that the follow-up period was only four to five years in 1966 as compared with five to ten years in 1976. In addition, Drance and Anderson did not have available the epinephrine testing (24 hours or seven days) for the 1966 study. Instead, they used the reported mean intraocular pressure values during the entire six- to 60-month period of treatment.
When the criteria of the 1976
Becker B, Shin DH, Kass MA, Kolker AE. Nonproprietary Name and Trademarks of Drug-Reply. Arch Ophthalmol. 1977;95(5):895. doi:10.1001/archopht.1977.04450050173024