[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.159.238.28. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 1977

Experimental Siderosis in the RabbitCorrelation Between Electroretinography and Histopathology

Author Affiliations

From the Division of Ophthalmology, Stanford University Medical Center, Stanford, Calif.

Arch Ophthalmol. 1977;95(6):1051-1058. doi:10.1001/archopht.1977.04450060138014
Abstract

• An iron foreign body was placed into the vitreous cavity of 22 rabbits' eyes. The electroretinographic (ERG) changes over a.15-week period were recorded. These changes were compared to those in a group of 12 normal rabbits and a group of 5 animals in whom a sham operation was performed. Twelve eyes were enucleated during this period and examined histopathologically.

Histopathologic and functional changes in siderosis were both progressive in time, but the ERG values were more consistent among the 22 animals than the morphologic changes. Iron oxidation (Fe[mi]Fe[mi]Fe3) was found and suggested to be the mediating factor of the direct Iron cytotoxic effect on the retina.

(Arch Ophthalmol 95:1051-1058, 1977)

×