• Twelve patients who had previously demonstrated an intolerance to topically applied epinephrine received dipivefrin 0.1% in one eye and epinephrine 2% in the other eye. An adverse reaction occurred in only one eye (8%) receiving dipivefrin, but in ten (83%) on epinephrine. Topical dipivefrin 0.1% proved useful for lowering intraocular pressure in patients intolerant to topically applied epinephrine.
(Arch Ophthalmol 95:2157-2158, 1977)
Yablonski ME, Shin DH, Kolker AE, Kass M, Becker B. Dipivefrin Use in Patients With Intolerance to Topically Applied Epinephrine. Arch Ophthalmol. 1977;95(12):2157-2158. doi:10.1001/archopht.1977.04450120063004