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December 1977

Ocular Tolerance of Bacillus Calmette-Guerin Organisms

Author Affiliations

From the Departments of Ophthalmology (Drs Rutgard, Frenkel, Peyman, and Stankevych, and Mr Saks) and Neurology and Neurosurgery (Dr Frenkel), University of Illinois, Abraham Lincoln School of Medicine, Chicago.

Arch Ophthalmol. 1977;95(12):2210-2213. doi:10.1001/archopht.1977.04450120116016

• The results of this investigation indicate that 5 x 106 and 5 x 108 viable bacillus Calmette-Guerin (BCG) organisms (Mycobacterium bovis strain) can be safely administered in the subconjunctival region of the eye of New Zealand albino rabbits without producing toxic effects locally or within the eye. This study provides a format for testing the applicability of BCG immunotherapy for experimental melanomas.

(Arch Ophthalmol 95:2210-2213, 1977)