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In Reply.—The title Dr Joseph suggests for our article would certainly be a good alternate one.
Most of our patients have been receiving epinephrine for five to six years, making it possible to evaluate the long-term effects of this therapy on the corneal endothelium. At the time therapy was started, endothelial cell measurements were not available. Since previous studies have shown similar measurements in both eyes of each patient, we believe the small, but significant, cell loss in the treated eye is due to the therapy. This occurs despite the lower intraocular pressure in the treated eye. A prospective study of the effects of various drugs on the corneal endothelium would certainly be worthwhile.
Waltman SR. Change Article Title-Reply. Arch Ophthalmol. 1977;95(12):2230. doi:10.1001/archopht.1977.04450120136023