[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.167.156.247. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1978

Retrolental FibroplasiaA New Analysis of Risk Factors Based on Recent Cases

Author Affiliations

From the Division of Ophthalmology (Dr Shahinian) and the Department of Pediatrics (Ms Malachowski), School of Medicine, Stanford (Calif) University Medical Center.

Arch Ophthalmol. 1978;96(1):70-74. doi:10.1001/archopht.1978.03910050034008
Abstract

• Over an 18-month period, four severe and eight mild cases of retrolental fibroplasia (RLF) were diagnosed. All infants had gestational age less than 34 weeks. While the percentage of infants with RLF increased with decreasing gestational age, the severity of RLF was not related to birth weight or gestational age. These RLF infants were compared with premature infants having normal fundi. The arterial blood gas values in the first week of life were similar for the two groups. However, during the subsequent weeks of oxygen therapy, the infants who developed severe RLF had a significantly greater number of hours of capillary oxygen tension at undesirable levels (Pcap O2 > 50 mm Hg) than the mild RLF or control infants. These results suggest that infants may be at greatest risk of severe retinal damage from oxygen relatively late in the course of their oxygen therapy.

×