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January 1978

Evaluation of Drugs in Ointment for Mydriasis and Cycloplegia

Author Affiliations

From the Departments of Ophthalmology and Pharmacology, University of Arkansas for Medical Sciences, Little Rock.

Arch Ophthalmol. 1978;96(1):84-86. doi:10.1001/archopht.1978.03910050048011

• Ointment preparations of cyclopentolate hydrochloride and tropicamide were compared with aqueous drops of these medications for the production of mydriasis and/or cycloplegia in clinic patients. Mydriasis and/or cycloplegia could be accomplished by the single application of a minute volume (around 0.005 ml) of ointment containing these drugs. With the use of ointment preparation, ocular irritation was minimal, and there was no interference with subsequent ocular examination. A delivery system was devised with a piece of silicone-rubber tubing that was filled with an ointment preparation. By squeezing the tubing, a minute volume (about 0.005 ml) of ointment preparation was expressed.