• Partial vitrectomies were performed on rabbits and the amount of vitreous removed was replaced with either 100% sulfur hexafluoride (SF6), 100% octofluorocyclobutane (freon-C318), 40% SF6, or air. Intraocular pressure and vitreous volume were determined. Replacing 40% of the initial vitreous volume with either 100% SF6 or 100% octofluorocyclobutane caused an increase over 20 mm Hg in the IOP with an associated loss of the remaining vitreous, whereas replacement with 40% SF6 or air caused no significant increase in IOP. Replacement with 40% SF6 caused a significant loss of the remaining vitreous, whereas the air replacement did not result in a vitreous loss. The experiments were repeated substituting only 20% of initial vitreous volume with 100% SF6 and 100% octofluorocyclobutane. Using this amount of SF6 and octofluorocyclobutane, the IOP did not increase but an associated vitreous loss occurred equal to twice the amount of SF6 injected and three times the amount of octofluorocyclobutane injected.
Killey FP, Edelhauser HF, Aaberg TM. Intraocular Sulfur Hexafluoride and OctofluorocyclobutaneEffects on Intraocular Pressure and Vitreous Volume. Arch Ophthalmol. 1978;96(3):511-515. doi:10.1001/archopht.1978.03910050279020