• Twenty-one patients under age 55 had idiopathic serous detachments of the retinal pigment epithelium (RPE) one-fifth disc diameter or larger in size. In the absence of other choroidal diseases, such as senile macular degeneration, presumed ocular histoplasmosis syndrome, or angioid streaks, serous RPE detachments have a good prognosis and probably are a variant of idiopathic central serous choroidopathy. The presence of associated subretinal fluid involving the macula was the factor that had the most effect on visual acuity. Serous detachments of the RPE should be distinguished from multiple vitelliform lesions (a variant of vitelliform dystrophy).
Lewis ML. Idiopathic Serous Detachment of the Retinal Pigment Epithelium. Arch Ophthalmol. 1978;96(4):620-624. doi:10.1001/archopht.1978.03910050316004