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Article
May 1978

Alteration of the Blood-Retinal Barrier in Experimental Diabetes Mellitus

Author Affiliations

From the Department of Ophthalmology, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1978;96(5):878-879. doi:10.1001/archopht.1978.03910050480018
Abstract

• Vitreous fluorophotometry was used to evaluate the integrity of the bloodretinal barrier to fluorescein in hooded rats. Streptozotocin-induced diabetes mellitus caused a breakdown of this barrier within ten days. Normalization of blood glucose levels with insulin significantly reduced (P <.005) the increased permeability. This functional microangiopathy might prove to be the earliest detectable change in the retinal circulation in experimental diabetes.

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