• The epinephrine pressure reduction was determined in 32 patients with elevated intraocular pressure (IOP) and 18 patients with untreated chronic open-angle glaucoma. The prevalence of responders was 53% of those patients with elevated IOP and 56% in those patients with open-angle glaucoma. This lack of difference between the two groups is suggestive of the need for caution before applying epinephrine in clinical practice as a predictive factor of future field loss.
Drance SM, Saheb NE, Schulzer M. Response to Topical Epinephrine in Chronic Open-Angle Glaucoma. Arch Ophthalmol. 1978;96(6):1001-1002. doi:10.1001/archopht.1978.03910050525004