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Article
June 1978

Intraocular Pressure Response to Topical Epinephrine and HLA-B12

Author Affiliations

From the Glaucoma Center, Washington University School of Medicine, St Louis. Dr Shin is now with the Department of Ophthalmology and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit.

Arch Ophthalmol. 1978;96(6):1012-1013. doi:10.1001/archopht.1978.03910050536007
Abstract

• Twenty high responders to topical corticosteroids (intraocular pressure > 31 mm Hg after six weeks of topical 0.1% dexamethasone, four times daily) and 20 low responders (IOP < 20 mm Hg) of similar age, sex, race, initial IOP, and facility of outflow were selected. After 24 hours of treatment (two doses) of topical 1% epinephrine hydrochloride, the high corticosteroid responders showed a mean (±SD) corrected decrease in IOP of 3.6 ± 2.0 mm Hg as opposed to 1.8 ± 2.1 mm Hg in the low corticosteroid responders. Within both corticosteroid groups, individuals with the antigen HLA-B12 showed significantly greater decreases in IOP. This suggested that the presence of HLA-B12 was not only associated with increased responses to corticosteroids but also to epinephrine.

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