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Article
September 1978

The Disc Sign in Sickling Hemoglobinopathies

Author Affiliations

From the Sickle Cell Eye Clinic, University of Illinois Eye and Ear Infirmary, Chicago. Dr Goldbaum is now with the Division of Ophthalmology, University of California, San Diego.

Arch Ophthalmol. 1978;96(9):1597-1600. doi:10.1001/archopht.1978.03910060231008
Abstract

• The disc sign is the presence of dark red spots on the optic disc of patients with a sickling hemoglobinopathy. The dark spots appear to be plugs of deoxygenated erythrocytes in small surface disc vessels. The occlusions, which are transient and do not produce clinically detectable visual impairment, were seen most often in patients with homozygous sickle cell anemia and may be the result of clogging of small vessels by irreversibly sickled erythrocytes.

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