• On routine examination, three patients demonstrated yellow-white lesions in the posterior third of the fundus. These lesions have a subtle but unique appearance. They are in the choroid and have definite borders, minimal or no elevation, a lack of secondary changes in the overlying pigment epithelium or neuroepithelium, and no pigment within the lesion or at its borders. Ophthalmoscopic and fluorescein angiographic data permit discussion of the differential diagnosis of these lesions. They may represent amelanotic nevi of the choroid.
Sigelman J, Jampol LM, Welch RB, Calkins JL. Amelanotic Small Flat Lesions of the Choroid. Arch Ophthalmol. 1978;96(10):1805-1808. doi:10.1001/archopht.1978.03910060317003