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November 1978

Iritis in Patients With Cutaneous Melanoma and Vitiligo

Author Affiliations

From the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, and Harvard Medical School, Boston (Dr Albert), and the Departments of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston (Drs Sober and Fitzpatrick).

Arch Ophthalmol. 1978;96(11):2081-2084. doi:10.1001/archopht.1978.03910060461015

• Two patients with cutaneous malignant melanoma, vitiligo, and uveitis are described. The occurrence of vitiligo following cutaneous melanoma is not uncommon and has been interpreted to result from cellular and humoral factors directed against melanoma cells that also destroy normal cutaneous melanocytes. The present cases raise the possibility that melanocytes in the eye as well as the skin may be affected.