• Histocompatibility (HLA) antigen typing was performed on 306 patients who had been studied and classified carefully. Black individuals with primary open-angle glaucoma (POAG) had no significant differences in HLA antigen prevalences from black control subjects. In one white population with POAG, a significant decrease in HLA-A1, a significant increase in HLA-Aw31, and a significant increase in the antigen combination HLAB7 and HLA-Bw22 were noted. However, these differences were not confirmed in a second white population with POAG. We concluded that associations between the A and B loci of the HLA antigen system and POAG were not as impressive as has been previously reported.
Kass MA, Palmberg P, Becker B, Miller JP. Histocompatibility Antigens and Primary Open-Angle GlaucomaA Reassessment. Arch Ophthalmol. 1978;96(12):2207-2208. doi:10.1001/archopht.1978.03910060509006