• Oral propranolol hydrochloride, 40 mg twice a day, and acetazolamide, 250 mg twice a day, were given in a randomized, double-masked, cross-over manner to eight patients with ocular hypertension. Each compound was given for eight weeks. Propranolol and acetazolamide produced a comparable decrease in intraocular pressure. Acetazolamide showed a clear orthostatic effect by significantly decreasing the standing systolic blood pressure (BP), while propranolol, at the doses used, had no obvious reducing effect on BP. Propranolol significantly decreased the pulse rate throughout the treatment period; acetazolamide also decreased the pulse rate, though slightly and not significantly. During treatment with acetazolamide a metabolic acidosis reflected by a decrease in the serum-CO2 combining power developed in five patients; this index remained unchanged during treatment with propranolol. Serum calcium, potassium, and sodium levels were not affected by propranolol or acetazolamide therapy.
Wettrell K, Pandolfi M. Propranolol vs AcetazolamideA Long-term Double-Masked Study of the Effect on Intraocular Pressure and Blood Pressure. Arch Ophthalmol. 1979;97(2):280-283. doi:10.1001/archopht.1979.01020010132006